Tailoring Anti-retroviral Therapy to Weight

EFAVIRENZ

• Adult : 600mg OD (similar as peads above 40kg)
• Dosage adjustment for concomitant rifampin (only if patient weighs ≥50 kg): Increase efavirenz dose to 800 mg once daily.
• Dosage adjustment for concomitant voriconazole: Reduce efavirenz dose to 300 mg once daily and increase voriconazole to 400 mg every 12 hours.

TENOFOVIR

1. Adult: 300mg OD (similar as peads above 35kg)

EMTRICITABINE

• Adult: 200mg OD (similar as peads above 33kg)

Effect of Weight on Dosing

• Virological and immunological responses to initial EFV-containing regimens were not impaired in heavy individuals, suggesting that the standard 600 mg EFV dosage is appropriate across a wide weight range
• A standard-dose efavirenz-based regimen is appropriate for HIV patients with tuberculosis who are receiving rifampin and have body weights of <60 kg

References:

1. www.lexi.comp
2. Body Weight Cutoff for Daily Dosage of Efavirenz and 60-Week Efficacy of Efavirenz-Based Regimen in Human Immunodeficiency Virus and Tuberculosis Coinfected Patients Receiving Rifampin http://aac.asm.org/content/53/10/4545.full
3. Standard Efavirenz Dose Appropriate for Overweight Patients http://www.thebodypro.com/content/75476/standard-efavirenz-dose-appropriate-for-overweight.html