Primary Immunization:
- For both adults and children, vaccine is administered subcutaneously as a single 0.5 ml dose.
- The vaccine can be given at the same time as other immunizations, if needed.
- Protective antibody levels may be achieved within 10-14 days after vaccination.
Revaccination:
- Revaccination may be indicated for individuals at high risk of infection, particularly children who were first immunized under 4 years of age; such children should be considered for revaccination after 2 or 3 years if they remain at high risk.
Reconstitution:
- The diluent is sterile pyrogen-free distilled water
- Draw the volume of diluent shown on the diluent label (6ml) into a suitable size syringe and inject into the vial containting the vaccine.
- Shake vial until the vaccine is dissolved.
- The vaccine when reconstituted is a clear colorless liquid.
- After reconstitution with diluent as indicated on the label, each 0.5 ml dose contains 50 mcg of "isolated product" from each of Groups A, C, Y and W-135
- Administer the vaccine subcutaneously.
- The immunizing dose is a single injection of 0.5 ml given subcutaneously.
- Store freeze-dried vaccine and reconstituted vaccine, when not in use between 2° - 8°C (35° - 45°F).
- Discard remainder of multidose vials of vaccine within 5 days after reconstitution.
Adverse reaction:
- Adverse reactions to meningococcal vaccine are mild and infrequent, consisiting of localized erythema lasting 1-2 days. Others include fever, malaise or headache.
- Up to 2% of young children develop fever transiently after vaccination.
- As with the administration of any vaccine, one should expect possible hypersensitivity reactions.
References:
- http://www.mydr.com.au/medicines/cmis/mencevax-acwy-powder-for-injection
- http://www.vaccineinfo.net/immunization/vaccine/meningococcal/meningitis_vaccine_insert.shtml
- Mencevax ACYW Product Leaflet
- MyBlueBook
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