- Conventional- amphotericin B deoxycholate (eg:Fungizone)
- Lipid-based formulations - Lipid complex (eg: ABLC, Abelcet), Cholesteryl complex (eg:colloidal dispersion, ABCD, Amphotec), Liposomal (eg: Ambisome)
- Conventional amphotericin B had more nephrotoxicity cases compared to Lipid-based amphotericin B
Conventional
|
Lipid-based
|
|
Nephotoxicity
|
49%
|
25%
|
Infusion Related (occur within 15 min to 3 hrs after initiation)
-
nausea,
vomiting, chills, and rigors,
|
30%
|
53%
|
- Amphotericin B generally is a nephrotoxic drug, and advised to use with caution in renal impaired patient according to product leaflet regardless of its formulation
REFERENCES
- www.uptodate.com
- Medscape
- www.drugs.com
- Product Leaflet
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