Monday, March 16, 2015

Cefuroxime for Skin and Soft Tissue Infection

  • Cefuroxime is indicated for skin and soft tissue infection  caused by Staphylococcus aureus (penicillinase- and non–penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp., and Enterobacter spp.
  • Based on our NAG 08, it can be used as an alternative for S.aureus infection in boils/carbuncles. Cefuroxime 500mg PO q12h for 7-10 days
  • Based on the coverage, can also be used as alternatives for Impetigo/cellulitis/erysipelas [S.aureus and S.pyogenes]
  • Based on IDSA 2014, Cefuroxime is also indicated for skin and tissue infection from human and animal bites.

Antibiotic Coverage :
Aerobes, Gram-positive: 
Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes (and other streptococci).
Aerobes, Gram-negative: 
Citrobacter spp., Enterobacter spp., Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains), Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella (Branhamella) catarrhalis (including ampicillin- and cephalothin-resistant strains), Morganella morganii (formerly Proteus morganii), Neisseria gonorrhoeae (including penicillinase- and non–penicillinase-producing strains), Neisseria meningitidis, Proteus mirabilis, Providencia rettgeri (formerly Proteus rettgeri), Salmonella spp., and Shigella spp.
Anaerobes:
 Gram-positive and gram-negative cocci (including Peptococcus andPeptostreptococcus spp.), gram-positive bacilli (including Clostridium spp.), and gram-negative bacilli (including Bacteroides and Fusobacterium spp.).

References:
  1. www.drugs.com
  2. IDSA Practice Guidelines for SSTIs (2014)
  3. National Antibiotic Guideline (2008) 

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