Comparison of pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV 23) administration

	PCV 13	PPSV 23
Serotypes	13 (1,3,4,5,6A, 6B,7F, 9V, 14, 18C, 19A, 19F, 23F)	23 (1,2,3,4,5,6B, 7F,8, 9N, 9V, 10A, 11A, 12F,14, 15B, 17F,18C, 19A, 19F, 29, 22F, 23F,33F)
Indication	Children < 5 years old Adults ≥ 65 years old 19-64 years old with medical conditions	Children ≥ 2 years with medical conditions Adults ≥ 65 years old 19-64 who smoke cigarette and asthma
Medical conditions	√ Immunocompromisingconditions √ Certain immunocompetent conditions (except chronic heart disease, chronic lung disease, diabetes mellitus, alcoholism, chronic liver disease and cigarette smoking) √ Functional or anatomic asplenia	√ Immunocompromising condition √ Immunocompetent condition √ Functional or anatomic asplenia
Repeat dose	No	Yes. Repeat at least 5 years after the first dose for person aged 19-64 years with medical conditions (except immunocompetent person)
Pregnancy	No recommendation	Recommended if some other risk factor is present)

Recommended intervals for PCV13 and PPSV 23 for adults aged ≥ 65 years old 

References:
1. http://www.immunize.org/askexperts/experts_pneumococcal_vaccines.asp
2. http://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule.pdf
3. www.cdc.gov/vaccines/vpd-vac/pneumo/vac-PV13-adults.htm