Wednesday, March 4, 2015

Dose equivalence: Etoricoxib and Celecoxib

EFFECTIVENESS
  • Osteoarthritis: Most studies showed that 30mg Etoricoxib is comparable to 200mg Celecoxib which is comparable to 2400mg Ibuprofen. A study suggested 30mg Etoricoxib is likely to show greater improvement in pain and physical function over 200mg Celecoxib.
  • Spondylitis: 90mg Etoricoxib was shown to be superior to 200/400mg Celecoxib
  • Post operative: 120mg Etoricoxib was shown to be superior to 400mg Celecoxib
  • No available studies comparing the equivalence of 60mg Etoricoxib with higher dosages of Celecoxib or greater frequency 
  • Preemptive analgesia for acute postoperative pain after athroscopic anterior cruciate ligament resconstruction: 120mg etoricoxib was shown to be superior to 400mg Celecoxib
SAFETY
  • Both agents are comparable in terms of safety
  • Etoricoxib has a higher rate of hypertension related adverse effect compared to Celecoxib
References:
  1. http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4290b1-02-Merck.pdf
  2. http://www.hindawi.com/journals/ijr/2011/160326/
  3. Comparing Etoricoxib and Celecoxib for Preemptive Analgesia for Acute Postoperative Pain in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial, BMC Musculoskelet Disord. 2010;11 
  4. Efficacy of Etoricoxib, Celecxib, Lumiracoxib, Non-selective NSAIDs and Acetominophen in Osteoarthritis: A mixed treatment comparison, Open Rheumatol J. 2012; 6: 6–20.

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