Dose equivalence: Etoricoxib and Celecoxib

EFFECTIVENESS

• Osteoarthritis: Most studies showed that 30mg Etoricoxib is comparable to 200mg Celecoxib which is comparable to 2400mg Ibuprofen. A study suggested 30mg Etoricoxib is likely to show greater improvement in pain and physical function over 200mg Celecoxib.

• Spondylitis: 90mg Etoricoxib was shown to be superior to 200/400mg Celecoxib

• Post operative: 120mg Etoricoxib was shown to be superior to 400mg Celecoxib

• No available studies comparing the equivalence of 60mg Etoricoxib with higher dosages of Celecoxib or greater frequency 

• Preemptive analgesia for acute postoperative pain after athroscopic anterior cruciate ligament resconstruction: 120mg etoricoxib was shown to be superior to 400mg Celecoxib

SAFETY

• Both agents are comparable in terms of safety

• Etoricoxib has a higher rate of hypertension related adverse effect compared to Celecoxib

References:

1. http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4290b1-02-Merck.pdf
2. http://www.hindawi.com/journals/ijr/2011/160326/
3. Comparing Etoricoxib and Celecoxib for Preemptive Analgesia for Acute Postoperative Pain in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial, BMC Musculoskelet Disord. 2010;11 
4. Efficacy of Etoricoxib, Celecxib, Lumiracoxib, Non-selective NSAIDs and Acetominophen in Osteoarthritis: A mixed treatment comparison, Open Rheumatol J. 2012; 6: 6–20.