Friday, April 24, 2015

Tailoring Anti-retroviral Therapy to Weight

EFAVIRENZ
  • Adult : 600mg OD (similar as peads above 40kg)
  • Dosage adjustment for concomitant rifampin (only if patient weighs ≥50 kg): Increase efavirenz dose to 800 mg once daily.
  • Dosage adjustment for concomitant voriconazole: Reduce efavirenz dose to 300 mg once daily and increase voriconazole to 400 mg every 12 hours.

TENOFOVIR
  1. Adult: 300mg OD (similar as peads above 35kg)

EMTRICITABINE
  • Adult: 200mg OD (similar as peads above 33kg)


Effect of Weight on Dosing
  • Virological and immunological responses to initial EFV-containing regimens were not impaired in heavy individuals, suggesting that the standard 600 mg EFV dosage is appropriate across a wide weight range
  • A standard-dose efavirenz-based regimen is appropriate for HIV patients with tuberculosis who are receiving rifampin and have body weights of <60 kg
References:
  1. www.lexi.comp
  2. Body Weight Cutoff for Daily Dosage of Efavirenz and 60-Week Efficacy of Efavirenz-Based Regimen in Human Immunodeficiency Virus and Tuberculosis Coinfected Patients Receiving Rifampin http://aac.asm.org/content/53/10/4545.full
  3. Standard Efavirenz Dose Appropriate for Overweight Patients http://www.thebodypro.com/content/75476/standard-efavirenz-dose-appropriate-for-overweight.html

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