Tuesday, May 26, 2015

Antiretroviral and Liver Injury

  • Antiretroviral drug-related liver injury is a common cause of morbidity, mortality and treatment discontinuation in HIV-infected patients,
  • Antiretroviral drug-related liver injury is defined by elevations in liver enzymes in serum, with ALT characteristically greater than AST.
  • After initiating HAART, the reported incidence of severe liver toxicity ranges from 2 to 18%.
  • Antiretroviral drug-related liver injury, especially severe toxicity, is clearly more frequent in HIV-infected patients with underlying chronic HBV and/or HCV infection.
  • Other predisposing factors are alcohol, consumption of ecstasy and cocaine; risk of liver injury is increased in those patients with transaminases elevations prior to initiating HAART

Potential and common Biochemical features


Drug related Liver Injury




References:
  1. Liver Disease and Cirrhosis PRIMARY CARE OF VETERANS WITH HIV Organ Systems and Metabolic. April 2009; Last reviewed/updated: October 28, 2011
  2. Soriano V. et al. Antiretroviral drugs and liver injury. AIDS. 2008 Jan 2;22(1):1-13.
  3. Antiretroviral Drugs and Liver Injury. http://www.medscape.com/viewarticle/568415_2

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