Treatment For Leprosy

Infection/Condition and Likely Organism	Preferred treatment	Alternative treatment
Hansen’s Disease (Leprosy) Mycobacterium Leprae	Paucibacillary Rifampicin 600mg PO monthly (supervised) PLUS Dapsone 100mg PO q24h Duration: 6 months (Completion of 6 doses within 9 months) Surveillance: 5 years Multibacillary Rifampicin 600mg PO monthly PLUS Clofazimine 300mg PO monthly PLUS Dapsone 100mg PO q24h PLUS Clofazimine 50mg PO q24h Duration: 1 year (if initial BI˂4) or 2 years (if BI≥4) Completion of 12 doses within 18 months (BI<4) Completion of 24 doses within 36 months ( BI≥4) Surveillance: 15 years	Bacterial resistance or hypersensitivity to first line Can be substituted with one of the following: Minocycline 100mg PO q24h OR Ofloxacin 400mg PO q24h OR Clarithromycin 500mg PO q24h OR Ethionamide 250mg PO q24h
Hansen’s Disease (Leprosy) in HIV	Same as non HIV patients	Same as non HIV patients

* Second line can only be initiated by a dermatologist

 
REFERENCE:
National Antibiotic Guideline 2014