Sunday, June 7, 2015

Treatment For Leprosy

Infection/Condition and Likely Organism
Preferred treatment
Alternative treatment
Hansen’s Disease (Leprosy)
Mycobacterium Leprae
Paucibacillary
Rifampicin 600mg PO monthly
(supervised)
PLUS
Dapsone 100mg PO q24h
Duration: 6 months
(Completion of 6 doses within 9 months)
Surveillance: 5 years
Multibacillary
Rifampicin 600mg PO monthly
PLUS
Clofazimine 300mg PO monthly
PLUS
Dapsone 100mg PO q24h
PLUS
Clofazimine 50mg PO q24h
Duration: 1 year (if initial BI˂4) or 2 years (if BI≥4)
Completion of 12 doses within 18 months (BI<4)
Completion of 24 doses within 36 months ( BI≥4)
Surveillance: 15 years
Bacterial resistance or hypersensitivity to first line
Can be substituted with one of the following:
Minocycline 100mg PO q24h
OR
Ofloxacin 400mg PO q24h
OR
Clarithromycin 500mg PO q24h
OR
Ethionamide 250mg PO q24h
Hansen’s Disease (Leprosy) in HIV

Same as non HIV patients

Same as non HIV patients


* Second line can only be initiated by a dermatologist
 
REFERENCE:
National Antibiotic Guideline 2014

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