Thyphoid Vaccinations

• Availability: Vi polysaccharide thyphoid vaccine, IV

Indication

• recommended for travelers (even short-term travelers) to areas where there is risk of exposure to S. typhi
• individuals with intimate exposure to a documented S. typhi chronic carrier (eg, household contacts),
• individuals whose work exposes them to cultures or specimens containing S. typhi (eg, laboratory workers)

Effectiveness:

• parenteral Vi polysaccharide vaccine was useful for inducing both direct and indirect protection (overall protection was 57 percent)
• Vaccination may be considered even after clinical illness, particularly in those not living in endemic areas, if re-exposure is expected
• Natural infection does not provide complete protection against recurrent illness (which is not the same as relapsed infection).

Contraindications or need to wait if

• Should not be given to children younger than 2 years of age.
• Anyone who has had a severe reaction to a previous dose of this vaccine should not get another dose.
• Anyone who has a severe allergy to any component of this vaccine should not get it. Tell your doctor if you have any severe allergies.
• Anyone who is moderately or severely ill at the time the shot is scheduled should usually wait until they recover before getting the vaccine.

Pregnancy

• Avoid oral vaccine which contains life vaccine
• Inadequate data for specific recommendation for IV Thyphoid vaccine
• As it is not critical for management of disease, can consider delaying vaccination till pregnancy is over

BreastFeeding

• There is no known risk to your baby if you are vaccinated with the typhoid vaccine while you are breastfeeding 

References:

1. Product Leaflet
2. http://www.cdc.gov/vaccines/pubs/preg-guide.htm#21
3. http://www.cdc.gov/vaccines/vpd-vac/should-not-vacc.htm#typhoid