Monday, December 28, 2015

Thyphoid Vaccinations

  • Availability: Vi polysaccharide thyphoid vaccine, IV
Indication
  • recommended for travelers (even short-term travelers) to areas where there is risk of exposure to S. typhi
  • individuals with intimate exposure to a documented S. typhi chronic carrier (eg, household contacts),
  • individuals whose work exposes them to cultures or specimens containing S. typhi (eg, laboratory workers)
Effectiveness:
  • parenteral Vi polysaccharide vaccine was useful for inducing both direct and indirect protection (overall protection was 57 percent)
  • Vaccination may be considered even after clinical illness, particularly in those not living in endemic areas, if re-exposure is expected
  • Natural infection does not provide complete protection against recurrent illness (which is not the same as relapsed infection).
Contraindications or need to wait if
  • Should not be given to children younger than 2 years of age.
  • Anyone who has had a severe reaction to a previous dose of this vaccine should not get another dose.
  • Anyone who has a severe allergy to any component of this vaccine should not get it. Tell your doctor if you have any severe allergies.
  • Anyone who is moderately or severely ill at the time the shot is scheduled should usually wait until they recover before getting the vaccine.
Pregnancy
  • Avoid oral vaccine which contains life vaccine
  • Inadequate data for specific recommendation for IV Thyphoid vaccine
  • As it is not critical for management of disease, can consider delaying vaccination till pregnancy is over
BreastFeeding
  • There is no known risk to your baby if you are vaccinated with the typhoid vaccine while you are breastfeeding 
References:
  1. Product Leaflet
  2. http://www.cdc.gov/vaccines/pubs/preg-guide.htm#21
  3. http://www.cdc.gov/vaccines/vpd-vac/should-not-vacc.htm#typhoid

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