Amphotericin B risk of nephrotoxicity

Amphotericin B

• Conventional- amphotericin B deoxycholate (eg:Fungizone)
• Lipid-based formulations - Lipid complex (eg: ABLC, Abelcet), Cholesteryl complex (eg:colloidal dispersion, ABCD, Amphotec), Liposomal (eg: Ambisome)
• Conventional amphotericin B had more nephrotoxicity cases compared to Lipid-based amphotericin B 

	Conventional	Lipid-based
Nephotoxicity	49%	25%
Infusion Related (occur within 15 min to 3 hrs after initiation) -         nausea, vomiting, chills, and rigors,	30%	53%

• Amphotericin B generally is a nephrotoxic drug, and advised to use with caution in renal impaired patient according to product leaflet regardless of its formulation

REFERENCES

1. www.uptodate.com
2. Medscape
3. www.drugs.com
4. Product Leaflet