Thursday, January 14, 2016

Amphotericin B risk of nephrotoxicity

Amphotericin B
  • Conventional- amphotericin B deoxycholate (eg:Fungizone)
  • Lipid-based formulations - Lipid complex (eg: ABLC, Abelcet), Cholesteryl complex (eg:colloidal dispersion, ABCD, Amphotec), Liposomal (eg: Ambisome)
  • Conventional amphotericin B had more nephrotoxicity cases compared to Lipid-based amphotericin B 


Conventional
Lipid-based
Nephotoxicity
49%
25%
Infusion Related (occur within 15 min to 3 hrs after initiation)
-         nausea, vomiting, chills, and rigors, 
30%
53%

  • Amphotericin B generally is a nephrotoxic drug, and advised to use with caution in renal impaired patient according to product leaflet regardless of its formulation

REFERENCES
  1. www.uptodate.com
  2. Medscape
  3. www.drugs.com
  4. Product Leaflet

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