Monday, January 25, 2016

Monitoring of Anticoagulant and Antiplatelet Therapy

Parameters for Anticoagulant and Antiplatelet Therapy

Parameters (Normal Range)
Factors Affected
International Normalized Ratio (INR) (1.0)
F7
Activated Partial Thromboplastin Time (30-40 seconds)
F12, F11, F9, F8
Prothrombin Time
(11 -12.5 seconds)
F7

PT Results
APTT Results
Bleeding time
Platelet count
Possible Condition
Prolonged
Prolonged
Unaffected
Unaffected
1.     Factor V deficiency
2.     Factor X deficiency
3.     Vit K def/ Warfarin
Prolonged
Prolonged
Prolonged
Decreased
1.     Disemminated intravascular coagulation
2.     Liver Failure end stage
Prolonged
Prolonged
Prolonged
Unaffected
1.     Congenital Afibrinogenemia
Unaffected
Prolonged
Prolonged
Unaffected
1.     Von Wilebrand disease
Unaffected
Prolonged
Unaffected
Unaffected
1.     Haemophilia
2.     Factor XII deficiency
Unaffected
Unaffected
Prolonged
Unaffected
1.     Aspirin
2.     Uremia
3.     Glazmann’s thrombasthenia
Unaffected
Unaffected
Prolonged
Unaffected/ Decreased
1.     Bernard-Soulier syndrome
Unaffected
Shortened
Unaffected
Unaffected
1.     C1INH deficiency


Coagulation cascade and site of action of anticoagulants


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