Monitoring of Anticoagulant and Antiplatelet Therapy

Parameters for Anticoagulant and Antiplatelet Therapy

Parameters (Normal Range)	Factors Affected
International Normalized Ratio (INR) (1.0)	F7
Activated Partial Thromboplastin Time (30-40 seconds)	F12, F11, F9, F8
Prothrombin Time (11 -12.5 seconds)	F7

PT Results	APTT Results	Bleeding time	Platelet count	Possible Condition
Prolonged	Prolonged	Unaffected	Unaffected	1.     Factor V deficiency 2.     Factor X deficiency 3.     Vit K def/ Warfarin
Prolonged	Prolonged	Prolonged	Decreased	1.     Disemminated intravascular coagulation 2.     Liver Failure end stage
Prolonged	Prolonged	Prolonged	Unaffected	1.     Congenital Afibrinogenemia
Unaffected	Prolonged	Prolonged	Unaffected	1.     Von Wilebrand disease
Unaffected	Prolonged	Unaffected	Unaffected	1.     Haemophilia 2.     Factor XII deficiency
Unaffected	Unaffected	Prolonged	Unaffected	1.     Aspirin 2.     Uremia 3.     Glazmann’s thrombasthenia
Unaffected	Unaffected	Prolonged	Unaffected/ Decreased	1.     Bernard-Soulier syndrome
Unaffected	Shortened	Unaffected	Unaffected	1.     C1INH deficiency

Coagulation cascade and site of action of anticoagulants