Friday, February 26, 2016

Medications In Anaphylaxis

DRUGS/INDICATION

CHILDREN

ADULTS

acute onset

0.01 mg/kg (as a 1:1000 solution) IM every 5-15 minutes, maximum 0.3 mg/dose;

0.3 to 0.5 mg (as a 1:1000 solution) IM every 5-15 minutes

cardiopulmonary arrest


severe hypotension


children: 0.01 mg/kg (as a 1:10,000 solution) intravenously every 3-5 minutes, maximum 1 mg/dose;

1 mg (as a 1:10,000 solution) intravenously every 3-5 minutes

children: 0.01 mg/kg (as a 1:10,000 solution) intravenously every 5 minutes, maximum 0.3 mg/dose;

0.1 mg (as a 1:10,000 solution) intravenously every 5 minutes

Adjunct severe hypotension

children: consult specialist for guidance on dose;

5 mg intravenously initially, may repeat in 10-15 min if no response, followed by 5-15 micrograms/min if response seen

persistent respiratory symptoms

children: 0.15 mg/kg nebulized every 20 minutes for 3 doses, then 0.15 to 0.3 mg/kg every 1-4 hours when required;

1.25 to 5 mg nebulized every 20 minutes for 3 doses, then every 1-4 hours when required

symptomatic hives and rhinorrhoea




+
children: 1-2 mg/kg intravenously/intramuscularly;
children: 1 mg/kg intravenously given over 5 minutes;

25-50 mg intravenously/intramuscularly


50 mg intravenously given over 5 minutes

post-emergency stabilisation



children and adults: 1-2 mg/kg/day intravenously

children and adults: 0.5 to 1 mg/kg/day orally

 references:
Best Practice/BMJ

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