Wednesday, February 24, 2016

Syrup Amoxycillin to Erythromycin Conversion




Amoxycillin
Erythromycin
Availability
125mg/5ml
EES 200mg/5ml
Dose
- 20 mg/kg/day 8 hrly.
Severe infections 
- 40 mg/kg/day 8 hrly

Mild-to-moderate infections:
- 30-50 mg/kg/day PO divided q6-12hr
Severe infection:
- 60-100 mg/kg/day PO divided q6-12hr
The recommended dosing schedule of erythromycin may result in gastrointestinal upset. Patients may require an alternative macrolide or a change to 3-times-daily dosing
Organisms
- provides good coverage of most infectious agents
- not effective against Mycoplasma and Legionella species
- staphylococcal and streptococcal infections
- most potential etiologic agents in rhinosinusitis, including Mycoplasma species
- less active against H influenzae
added advantage of being a good anti-inflammatory agent by inhibiting migration of polymorphonuclear leukocytes.

Reference:

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