Monday, March 14, 2016

Daflon: Renal Dose

Availability:
  • Diosmin 450mg/ Hesperidin 50mg
Recommendation: 
Based on Diosmin
  • In multiple clinical studies, the effects of diosmin in VASCULERA on blood chemistry as well as hepatic and renal function were compared to placebo in healthy subjects and patients with chronic venous insufficiency
  • No changes were noted in most studies with the exception of statistically significant decreases in creatinine levels in subjects taking diosmin in several clinical trials.
Supporting evidence
  • Lack of studies and evidence
  • Between January 2004 and October 2012, 1 individuals taking DAFLON (DIOSMIN) reported RENAL FAILURE ACUTE to the FDA
  • Based on some available studies, diosmin/hesperidin was used for studies of nephro-protective function in rats treated with Amphotericin B, showing an antioxidant protective effect on the kidneys.
  • In another study, Diosmin reduces CaOx deposition and the degeneration of glomeruli and tubules in a rat model of nephrolithiasis
References:
  1. http://pharmanatura.co.za/monographs/bottomline-hesperidin.htm?ajax=true&width=750&height=400
  2. http://therapy.epnet.com/nat/GetContent.asp?chunkiid=24379
  3. Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication. Rev Esc Enferm USP · 2015; 49(Esp):73-78
  4. http://online1.mimsgateway.com.my/
  5. Product Information VASCULERA®Tablets for oral administration
  6. http://factmed.com/report-DAFLON%20%20%28DIOSMIN%29-causing-RENAL%20FAILURE%20ACUTE.php
  7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630345/

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