Topical preparation containing antibiotic

Name	Antimicrobial coverage & uses
Mupirocin	inhibits bacterial protein synthesis           targets primarily Gram-positive organisms; S aureus (most MRSA) & most streptococci. Many Gram-negative pathogens, including enteric bacilli and other enterococci = not affected common use: localized impetigo due to S aureus & Streptococcus pyogenes  eradication of nasal colonization with S. aureus
Neomycin	interferes with bacterial protein synthesis. common use: treat infections by aerobic Gram-positive & Gram-negative bacilli (S aureus[Gram-positive] and E coli) prevent infection in superficial abrasions, cuts, and burns.
Fusidic acid	active against: Staphylococcus aureus, streptococci (in topical concentrations), corynebacteria, & clostridia  treat primary skin infections: impetigo contagiosa & erythrasma treat secondary skin infections: infected wounds & burns

*Topical mupirocin should be reserved for treating patients with localised mild skin infections (impetigo or infected eczema), that are resistant to fusidic acid and have sensitivity to mupirocin.

** Blue book indication for Mupirocin 2% Ointment: For MRSA infections only

References

1. http://www.medscape.org/viewarticle/457542_6

2. http://cid.oxfordjournals.org/content/49/10/1541.full

3. http://www.nursingtimes.net/clinical-archive/pain-management/topical-fusidic-acid/204084.fullarticle

4. http://www.bpac.org.nz/BPJ/2014/October/topical-antibiotics.aspx