Monday, August 15, 2016

Paraquat Poisoning : Fuller’s Earth

  • Fuller’s Earth is a calcium montmorillonite and it has been used as one of the treatment in Paraquat Poisoning
  • The mode of action is by tightly binding paraquat to the clay in the formulation, which takes place in thegastrointestinal tract and facilitates elimination in the feces.
  • Dosing and dilution of Fuller’s Earth :
    • Dosage form : 30% suspension
    • Recommended dose : 100-150 g for adults or 2 g/kg body weight in children
  • There is also some evidences showed the difference of concentration of Fuller’s Earth used in paraquat poisoning:
    • Dosage form : 15% suspension
    • Recommended dose : 100-150 g for adults or 2 g/kg body weight in children
HUSM FORMULARY
  • Dosage Form: Suspension 30% Fuller’s Earth
  • Recommended Dose: 300 ml of 30% Fuller’s Earth suspension every 2-4 hrs for several days.
DEPARTMENT Of MEDICAL SCIENCES, MINISTRY OF PUBLIC HEALTH THAILAND, 2005
  • Dosage and administration: 200-500ml of 30% Fuller's Earth suspension every 2 hours for 3 doses, in association with 5% w/v magnesium sulphate or mannitol to promote diarrhea and empty the gut.
Reference
  1. William N.R.  2007. Environmental and Occupational Medicine 4th Edition, Wolters Kluwer health /Lippincot Williams & Wilkins, Philadelphia. 1834pp
  2. http://www.kck.usm.my/husm/pharmacy/formulary/
  3. http://paraquat.com/sites/default/files/PQ%20Booklet%20Rev8%20final%201600212.pdf

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