SC Humalog Mix 50 Dosing & Dose Adjustment

Dosing Strategy

Patient	Dose	Frequency	Ref
Insulin naïve patient	5 units	BD (Breakfast & Dinner)	Product brochure
	Titration : every 3-4 days based on premeal BG to acheieve BG <6.1mmol/L
Converting from low mix twice daily	1/3 units from current dose	TDS ( Breakfast, Lunch & Dinner)
Converting from low mix three times daily (Twice daily Humalog Mix 50 & Once Daily Humalog Mix 25)	1/3 Humalog Mix50 (Breatkfast & Lunch) 1/3 Humalog Mix25 (Dinner)
For any diabetic population	5 to 10 units once or twice daily (prebreakfast and/or presupper). Titrate : 1 unit everyday until blood glucose reached target level		Diabetec.ca
Type 1 /Type 2 patient	Type 1 : 0.3-1U/kg/day in divided doses Type 2 : 0.5-1.5U/kg/day		Tarascon Pharmacopoeia 2014

Dose Adjustment 

Average glucose before meal (mmol/L)	Change in insulin dose	Ref
<4.4	-2	Product brochure
4.4-6.1	0
6.1-7.7	+2
7.7-11.1	+4

References: 

1. Product Brochure
2. http://guidelines.diabetes.ca/Browse/Appendices/Appendix
3. Eli Lilly Spokesperson 
4. http://guidelines.diabetes.ca/CDACPG_resources/Insulin_Prescription_May_5_2014.pdf