Friday, September 9, 2016

Cefuroxime Tablet & Suspension

Pharmacokinetic of Cefuroxime Axetil (Tablet)



Pharmacokinetic of Cefuroxime Axetil (Suspension)



Suspension –Tablet Conclusion
  • The absorption of cefuroxime from the suspension is more prolonged compared to tablets, leading to later, lower peak serum levels and slightly reduced systemic bioavailability (4-17% less) .
  • Cefuroxime axetil for oral suspension was not bioequivalent to cefuroxime axetil tablets when tested in healthy adults. 
  • The tablet and powder for oral suspension formulations are NOT substitutable on a milligram-per-milligram basis. 
  • The area under the curve for the suspension averaged 91% of that for the tablet, and the peak plasma concentration for the suspension averaged 71% of the peak plasma concentration of the tablets. 


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