Cefuroxime Tablet & Suspension

Pharmacokinetic of Cefuroxime Axetil (Tablet)

Pharmacokinetic of Cefuroxime Axetil (Suspension)

Suspension –Tablet Conclusion

• The absorption of cefuroxime from the suspension is more prolonged compared to tablets, leading to later, lower peak serum levels and slightly reduced systemic bioavailability (4-17% less) .
• Cefuroxime axetil for oral suspension was not bioequivalent to cefuroxime axetil tablets when tested in healthy adults. 
• The tablet and powder for oral suspension formulations are NOT substitutable on a milligram-per-milligram basis. 
• The area under the curve for the suspension averaged 91% of that for the tablet, and the peak plasma concentration for the suspension averaged 71% of the peak plasma concentration of the tablets.