Tuesday, September 20, 2016

Comparison : Amisulpride vs Sulpiride

Suggested Antipsychotic Treatment
Based on up to date evidence, first line recommended antipsychotic options are:
  • Amisulpride (greater comparative cost may outweigh first line choice).
  • Aripiprazole
  • Olanzapine (significant risk of metabolic adverse effects may outweigh first line choice).
  • Quetiapine
  • Risperidone
  • Sulpiride (greater comparative cost may outweigh first line choice).
Licensed ages (BNF for Children)
  • Amisulpiride : > 15 years
  • Sulpiride: > 14 years
Cost
Side effects
QT prolongation

Effect on Prolactin Levels


Breast feeding

Elderly

Conclusion
  • Amisulpride and Sulpiride are listed as the first line recommended antipsychotic.
  • There is not much different in the side effects of both drugs.
  • In terms of cost, sulpiride is cheaper than amisulpride.
References
  1. BNF, March –September 2016
  2. BNF for Children, September 2015-2016
  3. http://www.sussexpartnership.nhs.uk/
  4. http://www.malaysianpharma.com/index.php/articles22/

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