Wednesday, December 14, 2016

Benzodiazepine Comparison Chart

Benzodiazepine
Onset of Action2
Peak Onset (hrs)
Half-life
parent (hrs)

Half-life
metabolite (hrs)

Comparative
Oral Dose

Long Acting
Diazepam1
(Valium®)

Rapid (po, IV)
1(po)
20-50
3-100
5 mg
Intermediate  Acting
Alprazolam1
(Xanax®)

Int.
0.7-1.6
6-20
-
0.5mg
Clonazepam1
(Rivotril®)

Int.
1-4
18-39
-
0.25mg
Lorazepam1
(Ativan®)

Int. (po),
Rapid (sl, IV)

1-1.5 (po)
10-20
-
1mg
Short Acting
Midazolam1
(Versed®)

 Most  Rapid IV
0.5-1 (IV )
1-4
-
-
1 formulary drug
2 Rapid onset = within 15 minutes, Intermediate = 15-30 minutes, Slow = 30-60 minutes


References:
  1. http://clincalc.com/Benzodiazepine/?example
  2. http://emedicine.medscape.com/article/2172250-overview

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