Tranexamic Acid : Renal Adjustment

Availability:

• Tranexamic Acid Capsule 250mg
• Tranexamic Acid injection 100mg/ml

Rationale

• 90% excreted by glomerular filtration in 24h (IV)
• Thus there is a risk of accumulations in renal impaired patients
• Overdose symptoms include dizziness, headache, nausea, vomiting and diarrhoea. Orthostatic symptoms and hypotension may occur.

Renal Dose Adjustment:

• Dose and its adjustments are also dependent on the indications

Oral

GFR (ml/min)	Dose
30-60	1-1.5g , BD-TDS
10-30	1-1.5g , OD
<10 , Dialysis	0.5-1g , OD

Serum Creatine (mmol/L)	Dose
120-250	15mg/kg BD
250-500	15mg/kg OD
>500	7.5mg/kg OD

Intravenous

Serum Creatine (mmol/L)	Dose
120-250	10mg/kg BD
250-500	10mg/kg OD
>500	10mg/kg every 48h OR 5mg/kg OD

*Based on adjustment in dose for tooth extraction in patients with hemophilia

References:

1. http://www.globalrph.com/tranexamic_acid_dilution.htm
2. The Renal Drug Reference Guide, First Edition.
3. Product Leaflets