Thursday, January 26, 2017

Conversions : Amoxicillin to Phenoxymethyl Penicillin

  • In contrast to narrow spectrum penicillin G and V, amoxicillin has got a wide antibiotic spectrum and is effective against some gram negative rods too
  • Penicillin G and penicillin V are quite similar to each other but penicillin V is less effective against gram negative bacteria as compared to penicillin G
Disease specific
  • Amoxicillin is at least as effective as penicillin V for the treatment of streptococcal pharyngitis in children
  • Injectable penicillin and oral amoxicillin are equivalent for severe pneumonia in children aged 3-59 months
  • Both penicillin and amoxicillin are considered the first line of treatments for odontogenic infections.
Dosing for Pen V
  • The dosage and frequency of Phenoxymethylpenicillin depends on the severity and localisation of the infection and expected pathogens.
  • Phenoxymethylpenicillin Solution should be taken at least 30 minutes before or 2 hours after food, as ingestion of Phenoxymethylpenicillin with meals slightly reduces the absorption of the drug.
  • Phenoxymethylpenicillin 250mg is approximately equivalent to 400,000 units.
    • Adults/children over 12 years: 250mg - 500mg every six hours
    • Children: Infants (up to 1 year): 62.5mg every 6 hours
    • 1-5 years: 125mg every six hours
    • 6-12 years: 250mg every six hour
References
  1. http://www.emedexpert.com/compare-meds/amoxicillin-vs-penicillin.shtml
  2. http://medlicker.com/869-penicillin-vs-amoxicillin
  3. http://www.straighthealthcare.com/antibiotic-chart.html#penicillins
  4. https://www.medicines.org.uk/emc/medicine/27478

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