Sunday, January 8, 2017

PPI: Use in Pediatric

  • The literature on PPIs does not have well-defined age ranges for pediatric patients.
  • Some studies define children as patients 1 to 12 years old and adolescents as patients 13 to 17 years old. Other studies define children as patients 1 to 17 years old.
  • The ages of the patients were also inconsistent in the clinical trials conducted for medication approval.
Indications
  • Medications in the PPI drug therapy class have been proven safe and effective in children and adolescents for the short-term treatment of GERD and EE.
  • However, PPIs are often used to treat conditions that have not been formally diagnosed.
  • PPIs are used for the prevention and treatment of gastric acid related conditions.
  • These FDA-approved indications and age ranges apply to the prescribing of PPIs:
  • short-term treatment of symptomatic GERD and healing of EE
  • Only rabeprazole is FDA approved for the treatment of GERD in pediatric patients ages 1 to 11
  • No PPI is FDA approved for use in patients younger than one year old
  • Five of the six currently available PPIs have an FDA-approved indication for patients younger than 18 years old.

Reference:
Proton Pump Inhibitors: Use In Pediatric Patients. Education Medicaid Integrity Contractor for the CMS Medicaid Integrity Program (MIP).

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