Benzathine Penicillin : Renal Dose Adjustment

• No information available in drug information leaflets
• There are no dosage adjustments provided in the manufacturer’s labeling; use with caution

Adjustment

• 10-50 ml/min (75%)
• <10 ml/min (20-50%)
• HD : A maintenance dose may be given to patients following HD
• CAPD : 20 E 50% normal dose q 6 hr

Alternatives

• given the slow absorption and long half-life of penicillin G and published data indicating its safe use in the context of hemodialysis, the treating clinicians do decide in certain cases to proceed with penicillin G therapy at the usual dose

Reference:

1. Drug Information Leaflet
2. Dosing Information in Renal Impairment
3.  https://www.ncbi.nlm.nih.gov/pubmed/24644115