Drug Induced Hyponatremia

• Hyponatremia (defined as a serum sodium level <134 mmol/L) is a common electrolyte disturbance in clinical practice that is associated with considerable morbidity and mortality.
• As shown in evidence from small studies and case reports, drugs may cause hyponatremia by affecting sodium homeostasis and water homeostasis.
• Clinical information about the incidence and pathophysiological process of hyponatremia of the most commonly offending agents is presented in Table 1.
• Rarer causes derived from occasionally reported cases are presented in Table 2.

 

Reference:

Liamis, G., Milionis, H., & Elisaf, M. (2008). A review of drug-induced hyponatremia. American Journal of Kidney Diseases, 52(1), 144-153.