Vancomycin : Continuous Infusion

• Vancomycin exhibits time dependent killing, which implies that maintaining trough serum concentrations above the MIC is the most important determinant of therapeutic outcome.
• Vancomycin given as a continuous infusion avoids high peak concentrations and allows the maintenance of a steady state concentration above the MIC
• Additional benefits of a vancomycin continuous infusion include:
• Less nursing time required for administration
• Random vancomycin levels can be obtained for therapeutic drug monitoring
• Less cost of acquisition and wastage

 Dosing

 Dilution and Preparation

 Therapeutic Range

 

References:

1. Vancomycin Dosing - CHW. 23 February 2016
2. https://www.ncbi.nlm.nih.gov/pubmed/23172265
3. Vancomycin Dosing for Pediatrics University Health System