Thursday, May 25, 2017

Duolin Respules

Availability:
  • Ipratropium Bromide 0.5mg & salbutamol 2.5mg
  • Dosage (adults & > 12 years)
  • 1 respule 3-4 times daily
  • One unit dose (respule) provides prompt relief in most cases.
  • In severe cases, if an attack has not been relieved by one respule, two respules may be required
Administration
  • respules should be used undiluted.
Pharmacokinetic
  • For inhaled ipratropium is minimal, maximal responses usually develop over 30 to 90 minutes, lasting for four to six hours. 
  • The elimination half-life of ipratropium is approximately 3 to 4 hours after inhalation.
    For Salbutamol significant bronchodilation occurs within minutes of inhalation of a therapeutic dose, persisting for three to four hours. 
  • The elimination half-life of salbutamol is estimated to range from 4 to 6 hours.
Reference:
  • Duolin Respule Product Information Leaflet

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