Duolin Respules

Availability:

• Ipratropium Bromide 0.5mg & salbutamol 2.5mg
• Dosage (adults & > 12 years)
• 1 respule 3-4 times daily
• One unit dose (respule) provides prompt relief in most cases.
• In severe cases, if an attack has not been relieved by one respule, two respules may be required

Administration

• respules should be used undiluted.

Pharmacokinetic

• For inhaled ipratropium is minimal, maximal responses usually develop over 30 to 90 minutes, lasting for four to six hours. 
• The elimination half-life of ipratropium is approximately 3 to 4 hours after inhalation.
  For Salbutamol significant bronchodilation occurs within minutes of inhalation of a therapeutic dose, persisting for three to four hours. 
• The elimination half-life of salbutamol is estimated to range from 4 to 6 hours.

Reference:

• Duolin Respule Product Information Leaflet