Daflon:Chronic Venous Insufficiency

Availability in Hospital Keningau:

• Diosmin 450mg & Hesperidin 50mg Tablet

Product Information:

• There is no data on the duration of Daflon as per Product Information for Chronic Venous Insufficiency(CVI).

Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS):

• No duration indicated.
• According to guidelines, Relief study which included 5052 patients that received Micronised Purified Flavonoid Fraction (MPFF) over 6 months. MPFF significantly reduced symptoms and signs, and reduced ankle oedema.

Studies:

• There is a study in which patients were given Daflon 500mg twice daily for 6 months and patients showed progressive improvement from baseline in the symptoms of CVI.
• In another study, patients were given twice daily 500mg Daflon for 1 year, there were baseline values in physician-assessed clinical symptoms (functional discomfort, cramps and evening edema), ankle and calf circumference, and patient overall assessment of symptom severity was demonstrated at each 2-months evaluation.

References:

• Antignani, P. L., & Caliumi, C. (2007). Medical Treatment of Chronic Venous Insufficiency. Vascular Disease Prevention, 4(2), 117-124.
• Management of Chronic Venous Disease:Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)
• Daflon Product Information