Methylcobalamin vs Neurobion

Availability in Hospital Keningau:

• Neurobion (Vitamin B1, B6, B12)
• Mecobalamin 500 mcg Tab

Indication:

• According to FUKKM Neurobion is indicated for Vitamin B1, B6, B12 deficiencies.
• According to FUKKM Mecobalamin is indicated for peripheral neuropathies.

Peripheral Neuropathy:

• While Neurobion is not indicated for neuropathy, there was a study in which patients were prescribed Tab Neurobion for neuropathy.
• Efficacy was judged by documenting improvement in pain of at least 2 points from the baseline as assessed by numeric pain rating scale. Neurobion was found to be efficacious in 87.4% patient.
• In another study 108 patients with diabetic neuropathies were randomly assigned to the mecobalamin or the vitamin B 12 group
• After 12 weeks of treatment, in addition to the significant changes of symptoms in the mecobalamin group, nerve reflection and conduction velocity were also improved to a certain extent
• In a randomised, placebo-controlled, double-blind study in 50 patients with diabetic neuropathy. In this study, somatic and autonomic symptoms were significantly improved in the treatment group, although no statistical change was found in the neurophysiological studies.

Vitamin	NEUROBION	Individual Tab	RDA / for PN
B1 / Thiamine	100mg	10mg	·  5-30mg daily ·  Up to 300mg in deficiency
B6 / Pyridoxine	200mg	10mg	·  50-300mg ·  Doses above 1-6g can cause severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements)
B12 / Cyanocobalamin	200mcg	500mcg [mecobalamin]	·  50-6000mcg/day ·  Bioavailability 25%

References:

• RIZVI, A., AHMAD, A., & RIZVI, Z. Efficacy of Combination of Vitamin B1, B6 and B12 in Management of Diabetic Peripheral Neuropathy. age, 20(16), 5-1.
• https://www.ncbi.nlm.nih.gov/labs/articles/18491996/
• http://askdis.blogspot.my/2015/11/vitamin-b-for-peripheral-neuropathy.html