Vitamin C in reducing uric acid level

Availability in Hospital Keningau:

• Tablet Ascorbic Acid 100mg

Vitamin C as serum uric acid lowering:

• According to older research, consuming of vitamin C results serum uric acid reduction

• Research by Juraschek et al., 2010 state that, meta-analysis suggest that oral vitamin C supplementation results in modest SUA reduction.

• While, another research on 2012 conclude that, dietary vitamin C was shown to be more effective than vitamin C tablets in reduction of serum acid concentration 

Vitamin C NOT as serum acid lowering:

• Recent study on 2013 shown that supplemental vitamin C at a dosage of 500 mg/day does not lead to a clinically significant reduction in the SU level in patients with gout.

• The study shown that vitamin C may reduce the production of serum uric acid and risk of developing gout.

• No data that support the use of vitamin C supplementation as a urate-lowering therapy in patients with established gout.

Recommendation:

• Prescribing of vitamin C to gout patient for serum uric acid lowering were not indicated as recent study shown not significantly reduce in SUA level.

• Besides, according to latest FUKKM, vitamin C only indicated for vitamin C deficiency.

• May suggest to patient taking more dietary vitamin C instead of prescribing vitamin C tablet.

References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169708/pdf/nihms-300040.pdf
2. https://www.researchgate.net/publication/230562792_Implementing_High_Vitamin_C_Treatments_to_Decrease_Blood_Uric_Acid_Levels_in_Hyperuricemic_Saudi_Patients
3. http://onlinelibrary.wiley.com/doi/10.1002/art.37925/full
4. Formulary Ubat KKM August, 2017