Wednesday, January 17, 2018

Comparison between Povidone Iodine 10% and Acriflavine 0.1%

Availability in Hospital Keningau
  • Acriflavin 0.1% Lotion (Zontron)
  • Povidone Iodine 10% (Septidin 10%)

Table of comparison between Povidone and Acriflavin
Product
Acriflavine lotion 0.1%
Povidone Iodine 10% lotion
Indication
(As per Leaflet)
  • Treatment of infected wound or burns and for skin infections
  • Antiseptic against Bacteria, Fungi, Viruses, Protozoa, Cysts & Spores for minor burns, wounds & Pre operative Operation for the skin
Application
  • Apply a little on the affected parts and  spread gently 2-3 times per day
  • Pre operation preparation of the skin : Wet the operation site with water. Apply povidone, work up a lather using sterile gauze, scrub site for 5 minutes. Rinse off with water using wet sterile gauze. Paint the surgical site with Povidone 10% and permit to air dry
  • Minor burns, wounds skin infection: Apply twice daily to affected area with clean gauze or cotton bud
Coverage
  • Slow acting disinfectant, usually bacteriostatic against many gram negative bacteria and less effective against gram negative
  • Ineffective against spores

  • Broad-spectrum; effective against fungi, Gram-neg. and positive organisms, yeast, Protozoa and viruses.
   Remarks
  • Antiseptics, as an alternative for topical wound treatment, tend to be microbicidal and have a broader spectrum of antimicrobial activity than antibiotics
  • In comparison to most antibiotics, antiseptics reduce the likelihood of resistance emerging due to their multiple mechanisms of action targeting various aspects of cell biology in microbes
  • Overall, the properties of an ideal antiseptic include a broad spectrum of activity , the ability to penetrate biofilms , necrotic tissue, and eschar, a low potential for acquired resistance, supportive effects for wound healing by impeding excessive inflammation, and good local tolerability
  • Povidone has better spectrum of coverage compared to Acriflavine.
  • However as noted in product leaflet, Povidone should be used in caution and not to be used regularly in breastfeeding, pregnancy and in patients with thyroid disorder.
  • Povidone is also contraindicated in very low birth weight infants (below 1500g) and not to be used regularly in children below 2 years old and neonates.
  • However there is no specific information regarding Acriflavine in product information.

References
  • Acriflavine 0.1% Lotion (Zontron) Product Information
  • Povidone Iodine 10% ( Septidin) Product Information
  • http://www.edoc.co.za/modules.php?name=News&file=article&sid=393
  • https://www.sciencedirect.com/science/article/pii/S1743919117305368 






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