Topical Use: Glycerin VS Menthol ( in Aqueous Cream )

Glycerin is a humectant. Humectant is a conditioning agent that regulates water levels on the skin and hair in a distinct way. Due to their hygroscopicity, they are able to attract and bind water to themselves. Used topically as cream or lotion, it has conditioning benefits to the skin.

Other important humectants include sorbitol, propylene glycol and other polyhydric alcohols.

VS

Menthol works by triggering the cold receptors in the skin in order to provide a cooling and soothing relief. It is an alcohol obtained from oil of peppermint and derived from the mint plant.

It is classified as an irritant that produces a cooling sensation when used at 1.25-16%. The amount of menthol in many over the counter preparations (analgesics) ranges from 1-16%. It cools, calms and provides instant relief from certain skin conditions like pruritus.

Combined with camphor, it is used topically to relieve minor muscle or joint pain.

References:

1. Gesslein BW. Humectants in Personal Care Formulation: A Practical Guide. In the book: Conditioning Agents for Hair and Skin, Marcel Dekker Inc 1999.

2. Kwan ZA. Managing dry skin. In: MIMS Pharmacy Malaysia, March 2016.

3. Relieving Orthopedic Injury Pain. In the book: Therapeutic Modalities: The Art and Science. Lippincott Williams & Wilkins, 2008.

4. https://www.uwhealth.org/health/topic/multum/camphor-and-menthol-topical/d04844a1.html [Accessed 9 August 2019]