Thursday, April 2, 2020

Safety of Essential Phospholipid (Livovid - MAL06061350X) in Breastfeeding


Product Leaflet : Not mentioned

Active Ingredient
Recommendation during Breastfeeding
Lecithin
·         Supplemental lecithin has been recommended as a treatment for plugged milk ducts and as an additive to human milk that is given to preterm infants via pumping through plastic tubing in order to prevent fat loss.
·         No scientifically valid clinical studies exist on the safety and efficacy of high-dose lecithin supplementation in nursing mothers or infants. 
Thiamine
·         There are no data on the excretion of thiamine into human milk.
·         The manufacturer recommends that caution be used when administering thiamine to nursing women.
·         The recommended daily allowance (RDA) for thiamine during lactation is 1.4 mg/day regardless of a woman's age. Women who are breast-feeding more than one infant may have increased needs for thiamine.
Riboflavine
·         Safe to take during pregnancy and while breastfeeding, when taken in the dose recommended for your age and condition.
·         Any higher-than-recommended dose could have unknown effects on a pregnant woman's unborn baby.
·         Pregnant women shouldn't take more than 1.4 mg of riboflavin a day, and the recommended daily intake for breastfeeding women is 1.6 mg.
Pyridoxine
Caution is recommended.
Excreted into human milk: Yes

Comments:
-Pyridoxine needs are increased during lactation.
-Concentrations in breast milk are directly proportional to dietary intake.
-Very large pyridoxine doses are reported to inhibit lactation; doses closer to physiologic levels had no effect on lactation.
Cyanocobalamin
Use is not recommended; benefit to mother should outweigh risk to the infant. (AU)

Excreted into human milk: Yes
Nicotinamide
·         Niacin is actively excreted into breast milk.
·         It is unknown if niacinamide is excreted into breast milk, but it is probable that it also is actively transferred.
·         The National Academy of Sciences recommended dietary allowance for niacin is 20 mg. If the diet of the lactating woman adequately supplies this amount, supplementation with niacinamide is not needed.
·         Maternal supplementation with the RDA for niacinamide is recommended only for those patients with inadequate nutritional intake.
·         Niacinamide use in excess of the recommended daily allowance (RDA) during lactation should be avoided.
Vitamin E
Use is considered acceptable.
Excreted into human milk: Yes


Content per capsule:

Active Ingredient
Strength
Lecithin
500mg
Thiamine
3mg
Riboflavine
3mg
Pyridoxine
3mg
Cyanocobalamin
3mcg
Nicotinamide
15mg
Vitamin E
3.3mg


References:
  1. Product  Leaflet
  2. Lecithin https://www.ncbi.nlm.nih.gov/books/NBK501772/
  3. Thiamine Pregnancy and Breastfeeding Warnings Assessed from https://www.drugs.com/pregnancy/thiamine.html
  4. What Is Riboflavin (Vitamin B2)? https://www.everydayhealth.com/drugs/riboflavin
  5. Pyridoxine Pregnancy and Breastfeeding Warnings https://www.drugs.com/pregnancy/pyridoxine.html
  6. Cyanocobalamin Pregnancy and Breastfeeding Warnings https://www.drugs.com/pregnancy/cyanocobalamin.html
  7. Niacinamide Pregnancy and Breastfeeding Warnings https://www.drugs.com/pregnancy/niacinamide.html
  8. Vitamin e Pregnancy and Breastfeeding Warnings  https://www.drugs.com/pregnancy/vitamin-e.html


Prepared by Nur Nabiha R. on 10.03.2020

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.