Dosing of Mannitol 20% (Paediatrics) for Cerebral Edema

 

	Dose (g/kg)		Dose in ml/kg using Mannitol 20%	Frequency
Drug Doses Apps	0.25-0.5 g/kg		1.25-2.5 ml/kg	2H PRN, if serum osmolality <330 mmol/L
Lexicomp	0.25-1 g/kg over 20-30 min, up to 2 g/kg		1.25-5.0 ml/kg , up to 10 ml/kg	Repeat as needed to maintain serum osmolality 300-320 mOsm/kg
BNFC (v 3.0.1)	Administer over 30-60 min			Repeated if necessary , dose may be repeated 1-2x after 4-8 hours
	1 month – 11 years old	0.25-1.5 g/kg	1.25-7.5 ml/kg
	12-17 years old	0.25-2 g/kg	1.25- 10 ml/kg
BNFC 2016-2017	0.25-1.5 g/kg over 30-60 min		1.25-7.5 ml/kg	Repeated if necessary , dose may be repeated 1-2x after 4-8 hours

 

Prepared by Nabiha ; Edited by JCK Ho @ 04.09.2020