|
Reference |
Description |
|
Alistair G., Jane W.,
Vincent G., Lynn B. 2011. Injectable Drugs Guide. London:(PhP) Pharmaceutical
Press |
Patient-controlled analgesia: 1.
Make 500mg (10 mL) tramadol up to 50mL with NaCl 0.9% in a PCA
syringe to give a solution containing 10 mg/mL. 2.
The solution should be clear and colourless. Inspect visually
for particulate matter or discoloration prior to administration and discard
if present. 3.
The usual setting for the PCA device is to deliver a 5-mg
bolus with a 5-minute lock-out period. Lower doses are used in patients with
renal failure Strength used may vary
depending on local policies. Continuous
or intermittent intravenous infusion 1.
Withdraw the required dose and add to a suitable volume of
compatible infusion fluid (usually NaCl 0.9% or Gluc 5%). 2.
The solution should be clear and colourless. Inspect visually
for particulate matter or discoloration prior to administration and discard
if present. 3.
Give by continuous or intermittent IV infusion at a suitable
rate via a volumetric infusion device. 4.
Close monitoring of respiratory rate and consciousness is
recommended for 30 minutes in patients receiving an initial dose, especially
elderly patients or those of low bodyweight. Stability after
preparation: From a microbiological
point of view, should be used immediately; however, prepared infusions may be
stored at 2-8°C and infused (at room temperature) within 24 hours. |
|
https://anaesthesia.org.au/pain/pdf/Tramadol%20in%20Pain%20Management.pdf |
IV
injection/Infusion via Alaris® Infusion Pump: (for severe pain if oral
medications are not suitable eg/ post-operatively). · Preferably give as a IV
infusion to reduce nausea: · Dilute 50-100mg dose with
50-100mL of compatible solution and infuse over 30 -60 mins · IV Infusion may be given
faster (over 15mins) but is likely to cause nausea Loading dose of 100 mg -
usually given during surgery, followed by 50 to 100 mg every 4 to 6 hours. · If necessary give as a
bolus IV injection over 3-5minutes (nausea, vomiting and dizziness more
common with injection) · Compatible Solutions:
glucose 5%, sodium chloride 0.9%, Hartmann’s, Ringers. |
|
https://www.medicines.org.uk/emc/product/4405/smpc#gref
https://mri.cts-mrp.eu/human/downloads/PT_H_1548_001_FinalPI_2of3.pdf
|
Tramadol
Hydrochloride solution for injection/infusion can be mixed with the following
diluents for infusion over the concentration range of 0.5 - 4.0 mg/ml. •
0.9% Sodium Chloride Intravenous Infusion •
5% Dextrose Intravenous Infusion •
0.18% Sodium Chloride and 4% Dextrose Intravenous Infusion •
Ringer Lactate Solution • Haemaccel Shelf-life
in use: In
use: Tramadol
Hydrochloride solution for injection/infusion was found to be physically
compatible and chemically stable at controlled room temperature (i.e.
15-25°C) for up to 24 hours with 4.2% Sodium Bicarbonate Solution and
Ringer's solution or up to 5 days when mixed with the diluents as given in
section 6.6. From
a microbiological point of view, the product should be used immediately. If
not used immediately, in-use storage times and conditions prior to use are
the responsibility of the user and would not normally be longer than 24 hours
at 2 to 8°C, unless dilution has taken place in controlled and validated aseptic
conditions. |
|
Dilution Protocol 1st Edition
2017, Jabatan Kesihatan Negeri Selangor |
IV
infusion · Dilute with suitable
volume of diluents · Diluent: NS, D5 · Administer at a suitable
rate |
|
https://www.rch.org.au/anaes/pain_management/Opioid_Infusion/
|
(Paediatrics) · Add 4mg/kg to a
total of 50 mL diluent of choice (any IV maintenance solution of
electrolytes and/or glucose) to make infusion · Infuse at 0-4mL/hr: equivalent
to 0-0.32mg/kg/hr · Recommend bolus for pain
or painful procedures: 1-2mL (0.08-0.16 mg/kg) of infusion at
intervals of no less than 10 minutes Prepared on 02.09.2021 (J. Ho) |
