Antibiotic treatment for typhoid fever in pregnancy

• According to the jounals, the choice of antibiotics in pregnant patients is third generation cephalosporin and ampicillin/amoxicillin.
• However, due to ampicillin resistant in local setting, ampicillin or amoxycillin is not used.
• Based on .
• Sarawak Handbook, recommended antibiotics which are compatible with pregnancy (falls on Pregnancy category B) in uncomplicated typhoid includes:
• Ceftriaxone 2-3g IV for 7-10days
• Azithromycin D1 1000mg then 500mg daily for 7-14days/1000mg daily for 5-7days
• Cefotaxime 2g IV 8 hourly for 10-14days for severe typhoid.

1. http://www.ijidonline.com/article/S1201-9712(06)00187-1/fulltext

2. Sarawak Handbook of Medical Emergency 3rd Edition 2011