Monday, March 16, 2015

Suggested maintenance dose of phenytoin in ESRF patient

  • Phenytoin in ESRF patient tends to poorly bind to albumin and may have low serum albumin level. 
  • Therefore, maintenance dose of phenytoin needs to be titrated cautiously according to the response and unbound blood concentration. 
  • Monitoring should be done closely to ensure optimal efficacy and minimize toxicity.
References:
1. The Renal Drug Reference Guide 2008


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