Breastfeeding recommendations for Daflon

Manufacturers recommendations:

• In the absence of data concerning the diffusion into breast milk,breastfeeding is not recommended during treatment

Factors to Consider during Dosing: 

• Expression into breastmilk (in rats):
• passage into breast milk was assessed as 1% of the dose administered to the mother
• Volume of distribution is 60L. 
• the higher volume distribution means the lesser tendency to stay in the blood and will distribute to other body fluid
• Half life: 26-43hours. 
• Thus it takes about 1-2 days to achieve 50% of drug level in blood. 
• Some recommendations is to wait about 7-10 days (6-7 half life) before starting to breastfeed.
• Monitoring parameter: 
• based on pregnancy information in rat/mice, no teratogenicity was seen. 
• Thus no information of factors to monitor

References:

1. daflon 500mg.  http://www.mims.com/Malaysia/drug/info/Daflon%20500%20mg/?type=full
2. Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. http://www.ncbi.nlm.nih.gov/pubmed/8203791
3. Diosvein. http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0325-04-Tab-C-vol257.pdf
4. Daflon 500. http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0358-02-Submission-for-Diosmin-vol280.pdf