Comparison between Midazolam and Propofol for Sedation

	Midazolam	Propofol
USE	·         sedation, amnesia, ·         anxiolysis; ·         no analgesia ·         useful for many types of procedures; can combine with an analgesic	·         sedation ·         mild antiemetic effect ·         use for intubation, brief procedures (may redose for longer procedures)
ADVANTAGES	·         short duration ·         [onset: 5-15 min (20 with PR)] ·         minimal cardiovascular effects	·         very rapid return to baseline after discontinuing use
DISADVANTAGES	·         respiratory depression ·         (rate-dependent; give IV slowly), ·         duration may be prolonged with oral doses > 0.5 mg/kg	·         limited experience in children, use with caution ·         cost
	·         Both agents are comparable in terms of EFFICACY and SIDE EFFECT

REFERENCES:

1. Conscious sedation in interventional radiology: A comparison of Propofol versus Midazolam http://www.sedationconsulting.com/about/principals/143-propofol-vs-midazolam-article
2. UNIVERSITY OF VIRGINIA CHILDREN'S HOSPITAL PEDIATRIC SEDATION FOR DIAGNOSTIC AND THERAPEUTIC PROCEDURES