Thursday, March 5, 2015

Renal adjustment dose for patients with tuberculosis drug.

For renal impairment patient with SrCr<30mL/min and those receiving hemodialysis:

  • no changes for isoniazid and rifampicin
  • Pyrazinamide (25-30mg/kg) and Ethambutol (15-25mg/kg) changed to three times per week administration due to significant renal excretion of both drugs. 
  • Antituberculosis drug should be given after hemodialysis to prevent drug loss. 
References:
1. Clical Practice Guidelines: Management of Tuberculosis (3rd Edition)
2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092156/




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