Renal adjustment dose for patients with tuberculosis drug.

For renal impairment patient with SrCr<30mL/min and those receiving hemodialysis:

• no changes for isoniazid and rifampicin
• Pyrazinamide (25-30mg/kg) and Ethambutol (15-25mg/kg) changed to three times per week administration due to significant renal excretion of both drugs. 
• Antituberculosis drug should be given after hemodialysis to prevent drug loss. 

References:

1. Clical Practice Guidelines: Management of Tuberculosis (3rd Edition)
2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092156/