What is the preferred treatment which covers PCP & Toxoplasmosis?

Bactrim (TMP 15-20 mg and SMX 75-100 mg/kg/day) given 6 or 8 hourly for 6 weeks

• This is the first line treatment for PCP 
• Toxoplasmosis second line treatment regime is Bactrim (TMP 5 mg/kg and SMX 25mg/kg) IV or PO BD

OR

• Sulfadoxine/Pyrimethamine 500/25mg (Fansidar) PO 1 tab q12h + Folinic Acid 10-25mg PO q24h + Clindamycin 600mg IV/PO q6h for at least 6 weeks
• This is first line treatment for Toxoplasmosis 
• Second line treatment for PCP involves Pyrimethamine (Leucovorin) + Clindamycin 600mg IV/PO q6h
• Pyrimethamine dose : 200mg PO once then followed by body weight: ≤ 60kg 50mg PO daily, > 60kg 75mg PO daily

References: 

1. Aidsinfo.nih.gov/guidelines
2. National Antibiotic Guideline 2014