Wednesday, June 17, 2015

Interaction Between Bactrim and Folinic Acid

HIV patient currently being treated for PCP and Toxoplasmosis
  • First line treatment for PCP involves bactrim which has a major interaction with the first line treatment of toxoplasmosis which uses folinic acid
  • Interaction between folinic acid and bactrim
  • Treatment failure and excess mortality were observed when trimethoprim-sulfamethoxazole was used concomitantly with leucovorin for the treatment of HIV positive patients with Pneumocystis jiroveci pneumonia in a randomized placebo controlled trial. 
  • Co-administration of trimethoprim-  sulfamethoxazole and leucovorin during treatment of Pneumocystis jiroveci pneumonia should be avoided. 

References:

  1. http://www.drugs.com/disease-interactions/sulfamethoxazole-trimethoprim,bactrim.html
  2. http://www.rxlist.com/bactrim-drug/warnings-precautions.htm
  3. LEXICOMP 


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