Magnesium Trisilicate: Children & Pregnancy

Syrup Magnesium Trisilicate: 

• Mg Carbonate Light / Mg Trisilicate / Sodium Hydrogen Carbonate – all at 250mg/5ml

Tablet Magnesium Trisilicate: 

• Mg Trisilicate 250mg, Dried Aluminium Hydroxide 120mg

Children 

• Antacids are appropriate for short-term relief of heartburn in older children, adolescents, or adults with infrequent symptoms (less than once a week). 
• The efficacy and safety of antacids have not been well-studied, and chronic use is generally not recommended, especially in infants due to potential complications such as hypophosphatemic rickets

o    5-12 years: 5-10ml with water, TDS or as required

o    12-18 years: 10-20ml with water, TDS or as required

o    CHILD over 6 years: 1 tablet to be taken 3-4 times a day

Pregnancy & Lactation 

• Only limited data exist concerning the effects of antacids on the fetus with no controlled trials of efficacy. 
• Magnesium-, aluminium-, or calcium-containing antacids are not teratogeneic in animal studies although 15-30% of magnesium and a smaller percentage of aluminium preparations are absorbed after reacting with hydrochloric acid. 
• analysis of individual antacids (aluminium hydroxide, sodium bicarbonate, magnesium trisilicate and calcium carbonate) found no association with increased congenital anomalies. 
•  A recent European consensus conference recommended calcium/magnesium-based antacids for pregnant women because of their safety profile 
• Antacids should be taken at a different time than supplemental iron, because normal gastric acid facilitates the absorption of iron.

References:

1.      www.uptodate.com

2.      http://online1.mimsgateway.com.my/

3.      https://www.medicines.org.uk/emc/medicine/25289