Comparison : Amisulpride vs Sulpiride

Suggested Antipsychotic Treatment

Based on up to date evidence, first line recommended antipsychotic options are:

• Amisulpride (greater comparative cost may outweigh first line choice).
• Aripiprazole
• Olanzapine (significant risk of metabolic adverse effects may outweigh first line choice).
• Quetiapine
• Risperidone
• Sulpiride (greater comparative cost may outweigh first line choice).

Licensed ages (BNF for Children)

• Amisulpiride : > 15 years
• Sulpiride: > 14 years

Cost

Side effects

QT prolongation

Effect on Prolactin Levels

Breast feeding

Elderly

Conclusion

• Amisulpride and Sulpiride are listed as the first line recommended antipsychotic.
• There is not much different in the side effects of both drugs.
• In terms of cost, sulpiride is cheaper than amisulpride.

References

1. BNF, March –September 2016
2. BNF for Children, September 2015-2016
3. http://www.sussexpartnership.nhs.uk/
4. http://www.malaysianpharma.com/index.php/articles22/