Wednesday, February 15, 2017

Safety and Effectiveness: Cystone©



  • traditionally used for relief of a variety of urological problems including nephrolithiasis
  • shilapuspha (Didymocarpus pedicellata) 130mg, Pasanabheda (Saxifaga lgulata Syn. Bergenia ligulata/ciliata) 98 mg, Manjishtha (Rubia cordifolia) 32 mg, Nagarmusta (Cyperus scariosus) 32 mg, Apamarga (Achyranthes aspera) 32 mg, Gohija (Onosma bracteatum) 32 mg, Sahadevi (Vernonia cinerea) 32 mg, Shilajeet (Purified) 26 mg, and Hajrul yahood bhasma 32 mg
  • purported effect
    •  “prevent supersaturation of lithogenic substances, control oxamide (a substance that precipitates stone formation) from the intestine and correct the crystalloid-colloid imbalance
    • inhibits calculogenesis by reducing stone-forming substances like oxalic acid, calcium hydroxyproline, etc, and causes their expulsion by micropulverization
    • disintegration of the calculi and crystals by acting on the mucin, which binds the particles together
    • antimicrobial activity is beneficial in the prevention of urinary tract infections associated with urinary stones and crystalluria\
    • antispasmodic and anti-inflammatory activities relieve ureteric colic and alleviate symptoms of painful and burning and micturition.”

Effectiveness

  • Several herbs have been purported to decrease stone risk, or hasten stone passage. However, hard scientific evidence regarding their efficacy is scanty
  • The current results did not document any beneficial effect of Cystone® on the urinary composition.
  • However, the failure to find statistically significant change in urinary supersaturation does not rule out a beneficial effect
  • Cystone® is purported to promote stone passage. However, on average stone burden increased rather than decreased in our study.
  • No patient reported any side effects from Cystone®. This is in accord with previously published studies.
  • a meta analysis of 50 clinical studies however indicated that Cystone is useful in the management of Urolithiasis as revealed by the clearance of calculi, symptomatic relief, increased urine volume, and reduction in the stone forming constituents in urine with negligible adverse effects

Recommendations

  • Randomized controlled studies exist to support the efficacy of thiazides,7 allopurinol,8 and potassium magnesium citrate9 for secondary prevention of calcium oxalate kidney stones.
  • Side effects, cost, and imperfect prevention make the ready availability of cheap, safe and effective stone prevention therapy highly desirable

Reference:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925635/
  2. https://www.ayurtimes.com/cystone-tablets-syrup-benefits-uses-dosage-side-effects/
  3. http://ispub.com/IJAM/8/1/8636

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