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Wednesday, March 22, 2017

Benzathine Penicillin : Renal Dose Adjustment



  • No information available in drug information leaflets
  • There are no dosage adjustments provided in the manufacturer’s labeling; use with caution

Adjustment

  • 10-50 ml/min (75%)
  • <10 ml/min (20-50%)
  • HD : A maintenance dose may be given to patients following HD
  • CAPD : 20 E 50% normal dose q 6 hr

Alternatives

  • given the slow absorption and long half-life of penicillin G and published data indicating its safe use in the context of hemodialysis, the treating clinicians do decide in certain cases to proceed with penicillin G therapy at the usual dose

Reference:

  1. Drug Information Leaflet
  2. Dosing Information in Renal Impairment
  3.  https://www.ncbi.nlm.nih.gov/pubmed/24644115

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