Thursday, August 17, 2017

Fish Oil in Liver Disease


  • Fish oil is primarily composed of omega-3 fatty acids, which, along with omega-6 fatty acids, make up the essential fatty acids.

TPN associated Liver Disease

  • Subjects who received fish-oil–based emulsion experienced
    • reversal of cholestasis 4.8 times faster than those who received soybean emulsions
    • 6.8 times faster in analysis adjusted for baseline bilirubin concentration, gestational age, and the diagnosis of necrotizing enterocolitis

Oil-induced Fatty Liver

  • effects of dietary fish oil on fatty liver differ according to the cause of fatty liver; fish oil prevents sucrose-induced fatty liver but exacerbates safflower oil-induced fatty liver
  • The exacerbation of fatty liver may be due, at least in part, to increased expression of liver PPARgamma

Fatty Liver Disease

  • results of meta-analysis support the beneficial effect of n-3 PUFA (omega-3 fatty acid supplementation) in optimizing liver fat, liver enzyme levels (GGT), and blood lipid levels (TG, HDL) in patients with NAFLD
  • n-3 PUFAs may slow down the progress of NAFLD (nonalcoholic fatty liver disease)
  • a recent review by Parker et al., showed a benefit on liver fatness and found no significant benefit on ALT and AST levels

References

  1. http://pediatrics.aappublications.org/content/121/3/e678
  2. http://onlinelibrary.wiley.com/doi/10.1002/hep.21934/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019889/

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