Fish Oil in Liver Disease

• Fish oil is primarily composed of omega-3 fatty acids, which, along with omega-6 fatty acids, make up the essential fatty acids.

TPN associated Liver Disease

• Subjects who received fish-oil–based emulsion experienced
• reversal of cholestasis 4.8 times faster than those who received soybean emulsions
• 6.8 times faster in analysis adjusted for baseline bilirubin concentration, gestational age, and the diagnosis of necrotizing enterocolitis

Oil-induced Fatty Liver

• effects of dietary fish oil on fatty liver differ according to the cause of fatty liver; fish oil prevents sucrose-induced fatty liver but exacerbates safflower oil-induced fatty liver
• The exacerbation of fatty liver may be due, at least in part, to increased expression of liver PPARgamma

Fatty Liver Disease

• results of meta-analysis support the beneficial effect of n-3 PUFA (omega-3 fatty acid supplementation) in optimizing liver fat, liver enzyme levels (GGT), and blood lipid levels (TG, HDL) in patients with NAFLD
• n-3 PUFAs may slow down the progress of NAFLD (nonalcoholic fatty liver disease)
• a recent review by Parker et al., showed a benefit on liver fatness and found no significant benefit on ALT and AST levels

References

1. http://pediatrics.aappublications.org/content/121/3/e678
2. http://onlinelibrary.wiley.com/doi/10.1002/hep.21934/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019889/