Tuesday, August 15, 2017

Meropenam : Duration of Slow Infusion

  • Availability: IV Meropenam 500mg and 1g
Administration
  • Should be administered by IV infusion over approximately 15 minutes to 30 minutes.
  • Doses of 1 gram may also be administered as an IV bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes
Stability
  • Depended on diluent and storage condition
  • In Room Temperature: 8h for 0.9% NS, 2-3h for other diluents
  • At 2-8 ‘C : 24h for 0.9%NS, 8-14h for other diluents
Half Life:
  •  In subjects with normal renal function, the elimination half-life of is approximately 1 hour in adults, 1.5h for children <2 years
Rationale
  • Time-dependent agents
  • the maintenance of concentrations for about 40% of the dosing interval above the MIC of the pathogen (t > MIC) was found to be the pharmacodynamic target for maximal bactericidal activity in experimental animal models of infection
  •  Recent literature supports prolonged/extended infusion times of beta-lactam antibiotics as a way to maximize the time-dependent bactericidal activity and improve the probability of target attainment
Recommendation
  • If slow infusion is needed, treatment must always be started with a 1- to 2-g pulse loading dose administered over 30 min in order to promptly achieve therapeutically effective concentrations,
  • Continuous infusion should start immediately afterward loading dose
  • Reconstitution of the solution every 6 to 8 h (maximum) must be recommended for optimal use
References
  1. Medication Administration: Extended-Infusion Meropenem (Merrem®) Protocol
  2. http://aac.asm.org/content/56/12/6343.long
  3. https://www.drugs.com/pro/meropenem.html
  4. https://www.ncbi.nlm.nih.gov/pubmed/25230866

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