Comparison between Povidone Iodine 10% and Acriflavine 0.1%

Availability in Hospital Keningau

• Acriflavin 0.1% Lotion (Zontron)

• Povidone Iodine 10% (Septidin 10%)

Table of comparison between Povidone and Acriflavin

Product	Acriflavine lotion 0.1%	Povidone Iodine 10% lotion
Indication (As per Leaflet)	Treatment of infected wound or burns and for skin infections	Antiseptic against Bacteria, Fungi, Viruses, Protozoa, Cysts & Spores for minor burns, wounds & Pre operative Operation for the skin
Application	Apply a little on the affected parts and  spread gently 2-3 times per day	Pre operation preparation of the skin : Wet the operation site with water. Apply povidone, work up a lather using sterile gauze, scrub site for 5 minutes. Rinse off with water using wet sterile gauze. Paint the surgical site with Povidone 10% and permit to air dry Minor burns, wounds skin infection: Apply twice daily to affected area with clean gauze or cotton bud
Coverage	Slow acting disinfectant, usually bacteriostatic against many gram negative bacteria and less effective against gram negative Ineffective against spores	Broad-spectrum; effective against fungi, Gram-neg. and positive organisms, yeast, Protozoa and viruses.

   Remarks

• Antiseptics, as an alternative for topical wound treatment, tend to be microbicidal and have a broader spectrum of antimicrobial activity than antibiotics

• In comparison to most antibiotics, antiseptics reduce the likelihood of resistance emerging due to their multiple mechanisms of action targeting various aspects of cell biology in microbes

• Overall, the properties of an ideal antiseptic include a broad spectrum of activity , the ability to penetrate biofilms , necrotic tissue, and eschar, a low potential for acquired resistance, supportive effects for wound healing by impeding excessive inflammation, and good local tolerability

• Povidone has better spectrum of coverage compared to Acriflavine.

• However as noted in product leaflet, Povidone should be used in caution and not to be used regularly in breastfeeding, pregnancy and in patients with thyroid disorder.

• Povidone is also contraindicated in very low birth weight infants (below 1500g) and not to be used regularly in children below 2 years old and neonates.

• However there is no specific information regarding Acriflavine in product information.

References

• Acriflavine 0.1% Lotion (Zontron) Product Information

• Povidone Iodine 10% ( Septidin) Product Information

• http://www.edoc.co.za/modules.php?name=News&file=article&sid=393

• https://www.sciencedirect.com/science/article/pii/S1743919117305368